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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTPN1 All Species: 31.82
Human Site: S118 Identified Species: 70
UniProt: P18031 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P18031 NP_002818.1 435 49967 S118 N R V M E K G S L K C A Q Y W
Chimpanzee Pan troglodytes XP_512196 415 48479 E119 L N R I V E K E S V K C A Q Y
Rhesus Macaque Macaca mulatta XP_001096290 435 49928 S118 N R V M E K G S L K C A Q Y W
Dog Lupus familis XP_534455 424 48717 S118 N R V M E K G S L K C A Q Y W
Cat Felis silvestris
Mouse Mus musculus P35821 432 49575 S118 N R I M E K G S L K C A Q Y W
Rat Rattus norvegicus P20417 432 49656 S118 N R I M E K G S L K C A Q Y W
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508429 545 61767 S120 N R V M E K G S L K C A Q Y W
Chicken Gallus gallus O13016 434 50316 S118 N R V M E K G S I K C A Q Y W
Frog Xenopus laevis NP_001086085 428 49306 S120 N R V I E K G S I K C A Q Y W
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9W0G1 548 62086 K140 L M E K K Q I K C H L Y W P N
Honey Bee Apis mellifera XP_392429 495 55903 K133 I I E K N H V K C Y Q Y W P L
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 54 97.6 88.5 N.A. 82.9 84.3 N.A. 58.1 78.1 70.8 N.A. N.A. 34.1 40 N.A. N.A.
Protein Similarity: 100 69.8 99 92.8 N.A. 90.5 90.8 N.A. 66.2 86.9 82.3 N.A. N.A. 49.4 57.1 N.A. N.A.
P-Site Identity: 100 0 100 100 N.A. 93.3 93.3 N.A. 100 93.3 86.6 N.A. N.A. 0 0 N.A. N.A.
P-Site Similarity: 100 20 100 100 N.A. 100 100 N.A. 100 100 100 N.A. N.A. 13.3 0 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 73 10 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 19 0 73 10 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 19 0 73 10 0 10 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 73 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 10 0 0 0 10 0 0 0 0 0 % H
% Ile: 10 10 19 19 0 0 10 0 19 0 0 0 0 0 0 % I
% Lys: 0 0 0 19 10 73 10 19 0 73 10 0 0 0 0 % K
% Leu: 19 0 0 0 0 0 0 0 55 0 10 0 0 0 10 % L
% Met: 0 10 0 64 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 73 10 0 0 10 0 0 0 0 0 0 0 0 0 10 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 19 0 % P
% Gln: 0 0 0 0 0 10 0 0 0 0 10 0 73 10 0 % Q
% Arg: 0 73 10 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 73 10 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 55 0 10 0 10 0 0 10 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 19 0 73 % W
% Tyr: 0 0 0 0 0 0 0 0 0 10 0 19 0 73 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _